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positive surgical margins at radical prostatectomy predict

positive surgical margins at radical prostatectomy predict

positive surgical margins at radical prostatectomy predict

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Positive surgical margins at radical prostatectomy predict ...Positive surgical margins were associated with a 2.6-fold increased unadjusted risk of prostate cancer specific mortality (HR 2.55, 95% CI 2.02-3.21). Positive surgical margins remained an independent predictor of prostate cancer specific mortality on multivariate analysis (HR 1.70, 95% CI 1.32-2.18). Conclusions: These data demonstrate the independent role of positive surgical margins in prostateCited by: 238Publish Year: 2010Author: Jonathan L. Wright, Jonathan L. Wright, Bruce L. Dalkin, Lawrence D. True, William J. Ellis, Janet L...

What does a positive surgical margin actually predict positive surgical margins at radical prostatectomy predict

Feb 06, 2010 · Maybe 20-30 percent of all prostate cancer patients will be told, today, after a radical prostatectomy, that they a have a positive surgical margin. But exactly what impact a positive surgical margin has on a patients risk for disease recurrence has never been very clear. So that we are very clear, a positive surgical margin is an area on the edge of the prostate specimen, after surgical removal, that stains positive for prostate Significance of positive surgical margin and how to positive surgical margins at radical prostatectomy predictJun 15, 2018 · The target of radical prostatectomy [RP] was to completely resect the tumor. Positive surgical margins [PSM] following RP are associated with high risks of biochemical recurrence [BCR] and secondary treatment. This literature highlights the significance of PSM, how to manage and how the robotic radical prostatectomy could prevent it.Reporting positive surgical margins after radical positive surgical margins at radical prostatectomy predictBen Xu, Cheng Luo, Qian Zhang, Jie Jin, Preoperative characteristics of the P.R.O.S.T.A.T.E. scores: a novel predictive tool for the risk of positive surgical margin after radical prostatectomy, Journal of Cancer Research and Clinical Oncology, 10.1007/s00432-016-2313-2, 143, 4, (687-692), (2016).Cited by: 32Publish Year: 2013Author: Philip A. Fontenot, Ahmed M. Mansour, Ahmed M. Mansour

Prostate Cancer Surgery Positive Margins

Aug 22, 2020 · When surgical margins are positive, several studies show that immediate radiation to the prostate fossa will lower relapse rates and may slightly improve 10-year survival rates. However, since only 50% of men will relapse, waiting for evidence of a PSA rise before starting radiation may be a reasonable alternative.Preoperative MRI-based estimation of risk for positive positive surgical margins at radical prostatectomy predictJan 02, 2021 · To develop a simplified MRI-based model to predict the risk for positive surgical margins (PSMs) after radical prostatectomy (RP) in patients with prostate cancer (PCa). Consecutive patients who underwent RP for PCa were retrospectively identified from a tertiary referral hospital. Patients who underwent RP between January 2014 and June 2014 were assigned as derivation Author: Mi Yeon Park, Kye Jin Park, Mi-Hyun Kim, Jeong Kon KimPublish Year: 2021Preoperative MRI-based estimation of risk for positive positive surgical margins at radical prostatectomy predictJan 02, 2021 · Eur Radiol. 2021 Jan 2. doi: 10.1007/s00330-020-07569-z. Online ahead of print. ABSTRACT. OBJECTIVES: To develop a simplified MRI-based model to predict the risk for positive surgical margins (PSMs) after radical prostatectomy (RP) in patients with prostate cancer (PCa).

Predictors of positive surgical margins and their location positive surgical margins at radical prostatectomy predict

Small prostate volume was the predictor of positive apical margin in open prostatectomy (odds ratio 1.6, P =0.012), but for positive basal margin in robotic radical prostatectomy (odds ratio 4.5, P <0.001). In survival analysis, positive basal margin showed worse prognoses on Cited by: 7Publish Year: 2014Author: Min Soo Choo, Sung Yong Cho, Chang Wook Jeong, Seung Bae Lee, Ja Hyeon Ku, Sung Kyu Hong, Seok-Soo B positive surgical margins at radical prostatectomy predictPredictive Value of Positive Surgical Margins after positive surgical margins at radical prostatectomy predictPositive surgical margins play an important predictive role when estimating lymph node involvement in patients with locally advanced prostate carcinoma. Neoadjuvant antihormonal therapy is associated with a relevant reduction in the rate of positive margins but not with the rate of lymph node metastasis.Cited by: 1Publish Year: 2012Author: Wolfgang Otto, Peter Gerber, Wolfgang Rößler, Wolf Ferdinand Wieland, Stefan DenzingerPositive surgical margins in radical prostatectomy positive surgical margins at radical prostatectomy predictFeb 01, 2016 · Fingerprint Dive into the research topics of 'Positive surgical margins in radical prostatectomy patients do not predict long-term oncological outcomes: Results from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort'. Together they form a unique fingerprint. Cancer Care Facilities Medicine & Life SciencesCited by: 13Publish Year: 2016Author: Prabhakar Mithal, Lauren E. Howard, Lauren E. Howard, William J. Aronson, Martha K. Terris, Matthew positive surgical margins at radical prostatectomy predict

Positive surgical margins in radical prostatectomy positive surgical margins at radical prostatectomy predict

Epub 2015 Jun 23. Positive surgical margins in radical prostatectomy patients do not predict long-term oncological outcomes: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort. Mithal P (1), Howard LE (2) (3), Aronson WJ (4) (5), Terris MK (6) (7), Cooperberg MR (8), Kane CJ (9), Amling C (10), Freedland SJ (3) (11).Cited by: 13Publish Year: 2016Author: Prabhakar Mithal, Lauren E. Howard, Lauren E. Howard, William J. Aronson, Martha K. Terris, Matthew positive surgical margins at radical prostatectomy predictPositive surgical margins in radical prostatectomy positive surgical margins at radical prostatectomy predictPositive surgical margins in radical prostatectomy patients do not predict long-term oncological outcomes: Results from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort 2016 Author(s): Mithal, PCited by: 13Publish Year: 2016Author: Prabhakar Mithal, Lauren E. Howard, Lauren E. Howard, William J. Aronson, Martha K. Terris, Matthew positive surgical margins at radical prostatectomy predictPositive surgical margins following radical prostatectomy positive surgical margins at radical prostatectomy predictApr 16, 2016 · The incidence of positive surgical margins increases in cases of extracapsular extension, which occurs when cancer cells break through the prostate capsule. To eliminate the cancer, the surgeon may need to make a wider cut around the prostate, possibly sacrificing the neurovascular bundle.

Positive surgical margins at radical prostatectomy predict positive surgical margins at radical prostatectomy predict

Jun 01, 2010 · Positive surgical margins at radical prostatectomy predict prostate cancer-specific mortality: support for optimizing surgical technique and pathological evaluation at radical prostatectomy Jonathan L Wright , 1, 2 Bruce L. Dalkin , 1 Lawrence D True , 3 William J Ellis , 1 Janet L Stanford , 2 Paul H Lange , 1 and Daniel W Lin 1, 2Positive surgical margins at radical prostatectomy predict positive surgical margins at radical prostatectomy predictPositive surgical margins were associated with a 2.6-fold increased unadjusted risk of prostate cancer specific mortality (HR 2.55, 95% CI 2.02-3.21). Positive surgical margins remained an independent predictor of prostate cancer specific mortality on multivariate analysis (HR 1.70, 95% CI 1.32-2.18). Conclusions: These data demonstrate the independent role of positive surgical margins in prostate Cited by: 238Publish Year: 2010Author: Jonathan L. Wright, Jonathan L. Wright, Bruce L. Dalkin, Lawrence D. True, William J. Ellis, Janet L positive surgical margins at radical prostatectomy predictPositive surgical margins and biochemical recurrence positive surgical margins at radical prostatectomy predictOct 02, 2017 · The overall positive surgical margin rate was 30.6% In total 592 men underwent minimally invasive radical prostatectomy (MIRP) between 2002 and 2012. Median age at MIRP was 63 years (IQR 58-67 years). Median PSA at diagnosis was 7.9ng/ml (IQR 5.7-11.8ng/ml) and median follow-up was 52.8 months (IQR 25.0-73.6 months).Cited by: 9Publish Year: 2017Author: Ashwin Sachdeva, Ashwin Sachdeva, Rajan Veeratterapillay, Antonia Voysey, Katherine Kelly, Mark I. J positive surgical margins at radical prostatectomy predict

Positive surgical margins after radical prostatectomy: a positive surgical margins at radical prostatectomy predict

Positive surgical margins after radical prostatectomy: a systematic review and contemporary update Although positive margins in prostate cancer are considered an adverse oncologic outcome, their long-term impact on survival is highly variable and largely influenced by other risk modifiers.Cited by: 274Publish Year: 2014Author: Ofer Yossepowitch, Alberto Briganti, James A. Eastham, Jonathan Epstein, Markus Graefen, Rodolfo Mon positive surgical margins at radical prostatectomy predictPositive margin length and highest Gleason grade of tumor positive surgical margins at radical prostatectomy predictDec 11, 2017 · To evaluate the pathologic features after radical prostatectomy to determine if the length of positive surgical margin (PSM) and the highest Gleason grade within the tumor at the PSM could risk positive surgical margins at radical prostatectomy predictCited by: 7Publish Year: 2018Author: Brian F. Chapin, Jenny N. Nguyen, Mary F. Achim, Neema Navai, Stephen B. Williams, Ina N. Prokhorova positive surgical margins at radical prostatectomy predictPositive Surgical Margins at Radical Prostatectomy Predict positive surgical margins at radical prostatectomy predictThe presence of positive surgical margins (PSMs) after radical prostatectomy (RP) is associated with the risk of biochemical relapse and is considered a measure of surgical quality. 1 However positive surgical margins at radical prostatectomy predict

Positive Surgical Margins at Radical Prostatectomy Predict positive surgical margins at radical prostatectomy predict

Jun 01, 2010 · Positive surgical margins were associated with a 2.6-fold increased unadjusted risk of prostate cancer specific mortality (HR 2.55, 95% CI 2.023.21). Positive surgical margins remained an independent predictor of prostate cancer specific mortality on multivariate analysis (HR 1.70, 95% CI Cited by: 238Publish Year: 2010Author: Jonathan L. Wright, Jonathan L. Wright, Bruce L. Dalkin, Lawrence D. True, William J. Ellis, Janet L positive surgical margins at radical prostatectomy predictPositive Surgical Margins After Radical Prostatectomy: A positive surgical margins at radical prostatectomy predictFeb 01, 2014 · Positive surgical margins (PSMs) after radical prostatectomy (RP) are uniformly considered an adverse outcome associated with failure of the surgery to Cited by: 274Publish Year: 2014Author: Ofer Yossepowitch, Alberto Briganti, James A. Eastham, Jonathan Epstein, Markus Graefen, Rodolfo Mon positive surgical margins at radical prostatectomy predictPositive Surgical Margin after Radical Prostatectomy? What positive surgical margins at radical prostatectomy predictA positive surgical margin (PSM) after radical prostatectomy occurs in around 10-31% of cases, so researchers are very interested in understanding the clinical importance of a PSM. A team of scientists and doctors in Norway recently published a paper examining the effect of PSMs on patient outcomes. The paper can be viewed here.

High surgeon volume and positive surgical margins can positive surgical margins at radical prostatectomy predict

Does a surgeons annual radical prostatectomy volume predict the risk of positive surgical margins and urinary incontinence at one-year follow-up? Findings from a prospective national study . Scand J Urol 2013 ; 47: 92 100 .Cited by: 1Publish Year: 2019Author: Antonio Benito Porcaro, Alessandro Tafuri, Alessandro Tafuri, Marco Sebben, Nelia Amigoni, Tania Pro positive surgical margins at radical prostatectomy predictFrequency of Positive Surgical Margin at Prostatectomy and positive surgical margins at radical prostatectomy predictA positive surgical margin at prostatectomy is defined as tumor cells touching the inked edge of the specimen. This finding is reported in 8.8% to 42% of cases (median about 20%) in various studies. It is one of the main determinants of eventual biochemical (PSA) failure, generally associated with a doubled or tripled risk of failure. The effect of a positive margin on outcome can be modified by stage or grade and the length, number and location of positive margins, as well as by technical operative approach and durSee more on hindawi positive surgical margins at radical prostatectomy predictCited by: 21Publish Year: 2011Author: Kenneth A. Iczkowski, M. Scott LuciaExtent of positive surgical margins following radical positive surgical margins at radical prostatectomy predictMay 15, 2019 · The presence of positive surgical margins (PSM) following radical prostatectomy (RP) is a worrying for surgeons and patients alike as it represents an independent biochemical recurrence (BR) risk factor [ 1, 2, 3, 4, 5, 6, 7, 8 ]. The rate of PSM is 530% for organ-confined prostate cancer and 1765% for locally-advanced cancer [ 9, 10, 11 ].Cited by: 5Publish Year: 2019Author: Yoann Koskas, François Lannes, Nicolas Branger, Sophie Giusiano, Nicolas Guibert, Géraldine Pignot, positive surgical margins at radical prostatectomy predict

Does Gleason score of positive surgical margin after positive surgical margins at radical prostatectomy predict

Mar 01, 2020 · Positive surgical margin after radical prostatectomy remains controversial in its ability to predict long-term outcomes after surgery. To our knowledge, this is the first systematic review and meta-analysis investigating outcomes of patients after radical prostatectomy based on Gleason score of positive surgical margin site.Author: Athul John, Michael O'Callaghan, Rick Catterwell, Luke A SelthPublish Year: 2020Do Positive Surgical Margins Predict Biochemical positive surgical margins at radical prostatectomy predictIn previously published studies, which reported various outcomes, a high preoperative prostate-specific antigen (PSA) level, a high Gleason score (GS), high pathological stage, seminal vesicle invasion, large tumor volume, or positive surgical margin (PSM) could predict disease recurrence after RP [5-11]. However, not all patients with these predictive factors experience disease recurrence.Cited by: 5Publish Year: 2013Author: Jun Woo Lee, Jae Hyun Ryu, Yun Beom Kim, Seung Ok Yang, Jeong Kee Lee, Tae Young JungDo Positive Surgical Margins Predict Biochemical positive surgical margins at radical prostatectomy predictDo Positive Surgical Margins Predict Biochemical Recurrence in All Patients Without Adjuvant Therapy After Radical Prostatectomy? Jun Woo Lee, Jae Hyun Ryu1, Yun Beom Kim, Seung Ok Yang, Jeong Kee Lee, Tae Young Jung Department of Urology, Veterans Health Service Medical Center, Seoul, 1Department of Urology, Asan Health Center, Asan, Korea

Cancer Resection and Surgical Margins | Robotic positive surgical margins at radical prostatectomy predict

Aug 04, 2010 · The Decline of Positive Surgical Margins over Time Oncologic results from selected large contemporary open (retropubic and perineal) and standard laparoscopic radical prostatectomy series are listed in table I [25-31]. Positive margin rate ranged from 9%-24%. The largest series from Johns Hopkins, had 9035 RPs with 14.7% positive margins.Biochemical recurrence rate in patients with positive positive surgical margins at radical prostatectomy predictINTRODUCTION. In contemporary series, positive surgical margins (PSMs) occur in 1138% of patients undergoing radical prostatectomy (RP) [].PSMs have been associated with a greater risk of biochemical recurrence (BCR), with hazard ratios of 1.23.7 in recent series [].Given that randomized trials have reported a benefit for adjuvant radiotherapy after RP in patients with PSMs [2, 3], it is positive surgical margins at radical prostatectomy predictCited by: 9Publish Year: 2009Author: Farhang Rabbani, Kinjal C. Vora, Luis Herran Yunis, James A. Eastham, Bertrand Guillonneau, Peter T positive surgical margins at radical prostatectomy predict.

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